MEKK2 inhibits activation of MAP kinases in Arabidopsis.
Identifieur interne : 000119 ( Main/Exploration ); précédent : 000118; suivant : 000120MEKK2 inhibits activation of MAP kinases in Arabidopsis.
Auteurs : Yukino Nitta [Canada] ; Yichun Qiu [Canada] ; Hoda Yaghmaiean [Canada] ; Qian Zhang [Canada] ; Jianhua Huang [Canada] ; Keith Adams [Canada] ; Yuelin Zhang [Canada]Source :
- The Plant journal : for cell and molecular biology [ 1365-313X ] ; 2020.
Abstract
The Arabidopsis MEKK1-MKK1/MKK2-MPK4 kinase cascade is monitored by the nucleotide-binding leucine-rich-repeat immune receptor SUMM2. Disruption of this kinase cascade leads to activation of SUMM2-mediated immune responses. MEKK2, a close paralog of MEKK1, is required for defense responses mediated by SUMM2, the molecular mechanism of which is unclear. In this study, we showed that MEKK2 serves as a negative regulator of MPK4. It binds to MPK4 to directly inhibit its phosphorylation by upstream MKKs. Activation of SUMM2-mediated defense responses induces the expression of MEKK2, which in turn blocks MPK4 phosphorylation to further amplify immune responses mediated by SUMM2. Intriguingly, MEKK2 locates in a tandem repeat consisting of MEKK1, MEKK2 and MEKK3, which was generated from a recent gene duplication event, suggesting that MEKK2 evolved from a MAPKKK to become a negative regulator of MAP kinases.
DOI: 10.1111/tpj.14763
PubMed: 32267570
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</region></placeName></affiliation></author><author><name sortKey="Qiu, Yichun" sort="Qiu, Yichun" uniqKey="Qiu Y" first="Yichun" last="Qiu">Yichun Qiu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author><author><name sortKey="Yaghmaiean, Hoda" sort="Yaghmaiean, Hoda" uniqKey="Yaghmaiean H" first="Hoda" last="Yaghmaiean">Hoda Yaghmaiean</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author><author><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author><author><name sortKey="Huang, Jianhua" sort="Huang, Jianhua" uniqKey="Huang J" first="Jianhua" last="Huang">Jianhua Huang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author><author><name sortKey="Adams, Keith" sort="Adams, Keith" uniqKey="Adams K" first="Keith" last="Adams">Keith Adams</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author><author><name sortKey="Zhang, Yuelin" sort="Zhang, Yuelin" uniqKey="Zhang Y" first="Yuelin" last="Zhang">Yuelin Zhang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author></analytic><series><title level="j">The Plant journal : for cell and molecular biology</title><idno type="eISSN">1365-313X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Arabidopsis MEKK1-MKK1/MKK2-MPK4 kinase cascade is monitored by the nucleotide-binding leucine-rich-repeat immune receptor SUMM2. Disruption of this kinase cascade leads to activation of SUMM2-mediated immune responses. MEKK2, a close paralog of MEKK1, is required for defense responses mediated by SUMM2, the molecular mechanism of which is unclear. In this study, we showed that MEKK2 serves as a negative regulator of MPK4. It binds to MPK4 to directly inhibit its phosphorylation by upstream MKKs. Activation of SUMM2-mediated defense responses induces the expression of MEKK2, which in turn blocks MPK4 phosphorylation to further amplify immune responses mediated by SUMM2. Intriguingly, MEKK2 locates in a tandem repeat consisting of MEKK1, MEKK2 and MEKK3, which was generated from a recent gene duplication event, suggesting that MEKK2 evolved from a MAPKKK to become a negative regulator of MAP kinases.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32267570</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-313X</ISSN><JournalIssue CitedMedium="Internet"><Volume>103</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>07</Month></PubDate></JournalIssue><Title>The Plant journal : for cell and molecular biology</Title><ISOAbbreviation>Plant J</ISOAbbreviation></Journal><ArticleTitle>MEKK2 inhibits activation of MAP kinases in Arabidopsis.</ArticleTitle><Pagination><MedlinePgn>705-714</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/tpj.14763</ELocationID><Abstract><AbstractText>The Arabidopsis MEKK1-MKK1/MKK2-MPK4 kinase cascade is monitored by the nucleotide-binding leucine-rich-repeat immune receptor SUMM2. Disruption of this kinase cascade leads to activation of SUMM2-mediated immune responses. MEKK2, a close paralog of MEKK1, is required for defense responses mediated by SUMM2, the molecular mechanism of which is unclear. In this study, we showed that MEKK2 serves as a negative regulator of MPK4. It binds to MPK4 to directly inhibit its phosphorylation by upstream MKKs. Activation of SUMM2-mediated defense responses induces the expression of MEKK2, which in turn blocks MPK4 phosphorylation to further amplify immune responses mediated by SUMM2. Intriguingly, MEKK2 locates in a tandem repeat consisting of MEKK1, MEKK2 and MEKK3, which was generated from a recent gene duplication event, suggesting that MEKK2 evolved from a MAPKKK to become a negative regulator of MAP kinases.</AbstractText><CopyrightInformation>© 2020 Society for Experimental Biology and John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nitta</LastName><ForeName>Yukino</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Yichun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yaghmaiean</LastName><ForeName>Hoda</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Jianhua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>Keith</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yuelin</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0002-3480-5478</Identifier><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Plant J</MedlineTA><NlmUniqueID>9207397</NlmUniqueID><ISSNLinking>0960-7412</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Arabidopsis thaliana
</Keyword><Keyword MajorTopicYN="Y">MAP kinase</Keyword><Keyword MajorTopicYN="Y">MEKK2</Keyword><Keyword MajorTopicYN="Y">MPK4</Keyword><Keyword MajorTopicYN="Y">SUMM2</Keyword><Keyword MajorTopicYN="Y">plant immunity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>11</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32267570</ArticleId><ArticleId IdType="doi">10.1111/tpj.14763</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Asai, T., Tena, G., Plotnikova, J., Willmann, M.R., Chiu, W.L., Gomez-Gomez, L., Boller, T., Ausubel, F.M. and Sheen, J. (2002) MAP kinase signalling cascade in Arabidopsis innate immunity. Nature, 415(6875), 977-983.</Citation></Reference><Reference><Citation>Berriri, S., Garcia, A.V., Frei dit Frey N., Rozhon, W., Pateyron, S., Leonhardt, N., Montillet, J.L., Leung, J., Hirt, H. and Colcombet, J. (2012) Constitutively active mitogen-activated protein kinase versions reveal functions of Arabidopsis MPK4 in pathogen defense signaling. Plant Cell, 24(10), 4281-4293.</Citation></Reference><Reference><Citation>Bethke, G., Pecher, P., Eschen-Lippold, L., Tsuda, K., Katagiri, F., Glazebrook, J., Scheel, D. and Lee, J. (2012) Activation of the Arabidopsis thaliana mitogen-activated protein kinase MPK11 by the flagellin-derived elicitor peptide, flg22. Mol. Plant Microbe Interact. 25(4), 471-480.</Citation></Reference><Reference><Citation>Bi, D., Cheng, Y.T., Li, X. and Zhang, Y. (2010) Activation of plant immune responses by a gain-of-function mutation in an atypical receptor-like kinase. Plant Physiol. 153(4), 1771-1779.</Citation></Reference><Reference><Citation>Bi, G., Zhou, Z., Wang, W., Li, L., Rao, S., Wu, Y., Zhang, X., Menke, F.L.H., Chen, S. and Zhou, J.M. (2018) Receptor-like cytoplasmic kinases directly link diverse pattern recognition receptors to the activation of mitogen-activated protein kinase cascades in Arabidopsis. Plant Cell, 30(7), 1543-1561.</Citation></Reference><Reference><Citation>Century, K.S., Holub, E.B. and Staskawicz, B.J. (1995) NDR1, a locus of Arabidopsis thaliana that is required for disease resistance to both a bacterial and a fungal pathogen. Proc. Natl Acad. Sci. USA, 92(14), 6597-6601.</Citation></Reference><Reference><Citation>Edgar, R.C. (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32(5), 1792-1797.</Citation></Reference><Reference><Citation>Gao, M., Liu, J., Bi, D., Zhang, Z., Cheng, F., Chen, S. and Zhang, Y. (2008) MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants. Cell Res. 18(12), 1190-1198.</Citation></Reference><Reference><Citation>Glazebrook, J., Rogers, E.E. and Ausubel, F.M. (1996) Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening. Genetics, 143(2), 973-982.</Citation></Reference><Reference><Citation>Goodstein, D.M., Shu, S., Howson, R., Neupane, R., Hayes, R.D., Fazo, J., Mitros, T., Dirks, W., Hellsten, U. and Putnam, N. (2011) Phytozome: a comparative platform for green plant genomics. Nucleic Acids Res. 40(D1), D1178-D1186.</Citation></Reference><Reference><Citation>Hoang, D.T., Chernomor, O., Von Haeseler, A., Minh, B.Q. and Vinh, L.S. (2017) UFBoot2: improving the ultrafast bootstrap approximation. Mol. Biol. Evol. 35(2), 518-522.</Citation></Reference><Reference><Citation>Ichimura, K., Casais, C., Peck, S.C., Shinozaki, K. and Shirasu, K. (2006) MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis. J. Biol. Chem. 281(48), 36 969-36 976.</Citation></Reference><Reference><Citation>Jones, J.D. and Dangl, J.L. (2006) The plant immune system. Nature, 444(7117), 323-329.</Citation></Reference><Reference><Citation>Kalyaanamoorthy, S., Minh, B.Q., Wong, T.K., von Haeseler, A. and Jermiin, L.S. (2017) ModelFinder: fast model selection for accurate phylogenetic estimates. Nat. Methods, 14(6), 587.</Citation></Reference><Reference><Citation>Kong, Q., Qu, N., Gao, M. et al. (2012) The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis. Plant Cell, 24(5), 2225-2236.</Citation></Reference><Reference><Citation>Kong, Q., Sun, T., Qu, N., Ma, J., Li, M., Cheng, Y.T., Zhang, Q., Wu, D., Zhang, Z. and Zhang, Y. (2016) Two redundant receptor-like cytoplasmic kinases function downstream of pattern recognition receptors to regulate activation of SA biosynthesis. Plant Physiol. 171(2), 1344-1354.</Citation></Reference><Reference><Citation>Li, B., Jiang, S., Yu, X., Cheng, C., Chen, S., Cheng, Y., Yuan, J.S., Jiang, D., He, P. and Shan, L. (2015) Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity. Plant Cell, 27(3), 839-856.</Citation></Reference><Reference><Citation>MAPK-Group (2002) Mitogen-activated protein kinase cascades in plants: a new nomenclature. Trends Plant Sci. 7(7), 301-308.</Citation></Reference><Reference><Citation>Nakagami, H., Soukupova, H., Schikora, A., Zarsky, V. and Hirt, H. (2006) A Mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis. J. Biol. Chem. 281(50), 38 697-38 704.</Citation></Reference><Reference><Citation>Nguyen, L.-T., Schmidt, H.A., von Haeseler, A. and Minh, B.Q. (2014) IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol. Biol. Evol. 32(1), 268-274.</Citation></Reference><Reference><Citation>Nitta, Y., Ding, P. and Zhang, Y. (2014) Identification of additional MAP kinases activated upon PAMP treatment. Plant Signal. Behav. 9(11), e976155.</Citation></Reference><Reference><Citation>Pitzschke, A., Djamei, A., Bitton, F. and Hirt, H. (2009) A major role of the MEKK1-MKK1/2-MPK4 pathway in ROS signalling. Mol. Plant, 2(1), 120-137.</Citation></Reference><Reference><Citation>Qiu, J.L., Zhou, L., Yun, B.W., Nielsen, H.B., Fiil, B.K., Petersen, K., Mackinlay, J., Loake, G.J., Mundy, J. and Morris, P.C. (2008) Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1. Plant Physiol. 148(1), 212-222.</Citation></Reference><Reference><Citation>Stamatakis, A. (2014) RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics, 30(9), 1312-1313.</Citation></Reference><Reference><Citation>Su, S.H. and Krysan, P.J. (2016) A double-mutant collection targeting MAP kinase related genes in Arabidopsis for studying genetic interactions. Plant J. 88(5), 867-878.</Citation></Reference><Reference><Citation>Su, S.H., Bush, S.M., Zaman, N., Stecker, K., Sussman, M.R. and Krysan, P. (2013) Deletion of a tandem gene family in Arabidopsis: increased MEKK2 abundance triggers autoimmunity when the MEKK1-MKK1/2-MPK4 signaling cascade is disrupted. Plant Cell, 25(5), 1895-1910.</Citation></Reference><Reference><Citation>Suarez-Rodriguez, M.C., Adams-Phillips, L., Liu, Y., Wang, H., Su, S.H., Jester, P.J., Zhang, S., Bent, A.F. and Krysan, P.J. (2007) MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants. Plant Physiol. 143(2), 661-669.</Citation></Reference><Reference><Citation>Sun, T., Nitta, Y., Zhang, Q., Wu, D., Tian, H., Lee, J.S. and Zhang, Y. (2018) Antagonistic interactions between two MAP kinase cascades in plant development and immune signaling. EMBO Rep. e45324.</Citation></Reference><Reference><Citation>Teige, M., Scheikl, E., Eulgem, T., Doczi, R., Ichimura, K., Shinozaki, K., Dangl, J.L. and Hirt, H. (2004) The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis. Mol. Cell, 15(1), 141-152.</Citation></Reference><Reference><Citation>Trifinopoulos, J., Nguyen, L.-T., von Haeseler, A. and Minh, B.Q. (2016) W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis. Nucleic Acids Res. 44(W1), W232-W235.</Citation></Reference><Reference><Citation>Van Bel, M., Diels, T., Vancaester, E., Kreft, L., Botzki, A., Van de Peer, Y., Coppens, F. and Vandepoele, K. (2017) PLAZA 4.0: an integrative resource for functional, evolutionary and comparative plant genomics. Nucleic Acids Res. 46(D1), D1190-D1196.</Citation></Reference><Reference><Citation>Wang, X., Wu, J., Liang, J., Cheng, F. and Wang, X. (2015) Brassica database (BRAD) version 2.0: integrating and mining Brassicaceae species genomic resources. Database, 2015, bav093.</Citation></Reference><Reference><Citation>Zhang, Z., Wu, Y., Gao, M., Zhang, J., Kong, Q., Liu, Y., Ba, H., Zhou, J. and Zhang, Y. (2012) Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2. Cell Host Microbe, 11(3), 253-263.</Citation></Reference><Reference><Citation>Zhang, Z., Liu, Y., Huang, H., Gao, M., Wu, D., Kong, Q. and Zhang, Y. (2017) The NLR protein SUMM2 senses the disruption of an immune signaling MAP kinase cascade via CRCK3. EMBO Rep. 18(2), 292-302.</Citation></Reference><Reference><Citation>Zhao, C., Nie, H., Shen, Q., Zhang, S., Lukowitz, W. and Tang, D. (2014) EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity. PLoS Genet. 10(5), e1004389.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Colombie-Britannique </li></region><settlement><li>Vancouver</li></settlement><orgName><li>Université de la Colombie-Britannique</li></orgName></list><tree><country name="Canada"><region name="Colombie-Britannique "><name sortKey="Nitta, Yukino" sort="Nitta, Yukino" uniqKey="Nitta Y" first="Yukino" last="Nitta">Yukino Nitta</name></region><name sortKey="Adams, Keith" sort="Adams, Keith" uniqKey="Adams K" first="Keith" last="Adams">Keith Adams</name><name sortKey="Huang, Jianhua" sort="Huang, Jianhua" uniqKey="Huang J" first="Jianhua" last="Huang">Jianhua Huang</name><name sortKey="Qiu, Yichun" sort="Qiu, Yichun" uniqKey="Qiu Y" first="Yichun" last="Qiu">Yichun Qiu</name><name sortKey="Yaghmaiean, Hoda" sort="Yaghmaiean, Hoda" uniqKey="Yaghmaiean H" first="Hoda" last="Yaghmaiean">Hoda Yaghmaiean</name><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><name sortKey="Zhang, Yuelin" sort="Zhang, Yuelin" uniqKey="Zhang Y" first="Yuelin" last="Zhang">Yuelin Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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